Eileen Socher

2025

• Dobert J., Schäfer JH., Dal Maso T., Ravindran P., Huard DJE., Socher E., Schildmeyer LA., Lieberman RL., Versées W., Moeller A., Zunke F., Arnold P.:
  Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2
  In: Nature Communications 16 (2025), Art.Nr.: 3074
  ISSN: 2041-1723
  DOI: 10.1038/s41467-025-58340-1
• Zahn I., Socher E., Bergua A., Schikorra T., Kleinsasser B., Garreis F., Schicht M., Dietrich J., Paulsen F.:
  Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo
  In: Biomedicine & Pharmacotherapy 185 (2025), S. 117937
  ISSN: 0753-3322
  DOI: 10.1016/j.biopha.2025.117937

2024

• Gleixner S., Zahn I., Dietrich J., Singh S., Drobny A., Schneider Y., Schwendner R., Socher E., Blavet N., Bräuer L., Gostian AO., Balk M., Schulze-Tanzil G., Günther C., Paulsen F., Arnold P.:
  A New Immortalized Human Lacrimal Gland Cell Line
  In: Cells 13 (2024), S. 622
  ISSN: 2073-4409
  DOI: 10.3390/cells13070622
• Marschall M., Schütz M., Wild M., Socher E., Wangen C., Dhotre K., Rawlinson WD., Sticht H.:
  Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target
  In: Cells 13 (2024), S. 1338
  ISSN: 2073-4409
  DOI: 10.3390/cells13161338
• Stahl-Hennig C., Peter AS., Cordsmeier A., Stolte-Leeb N., Vestweber R., Socher E., Merida SA., Sauermann U., Bleyer M., Fraedrich K., Grunwald T., Winkler T., Enßer A., Jäck HM., Überla K.:
  Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model
  In: Journal of Virology (2024)
  ISSN: 0022-538X
  DOI: 10.1128/jvi.00628-24

2023

• German A., Jukic J., Laner A., Arnold P., Socher E., Mennecke A., Schmidt M., Winkler J., Abicht A., Regensburger M.:
  Novel Homozygous FA2H Variant Causing the Full Spectrum of Fatty Acid Hydroxylase-Associated Neurodegeneration (SPG35)
  In: Genes 15 (2023), S. 14
  ISSN: 2073-4425
  DOI: 10.3390/genes15010014
• Heger L., Hatscher L., Liang C., Lehmann C., Amon L., Lühr JJ., Kaszubowski T., Nzirorera R., Schaft N., Dörrie J., Irrgang P., Tenbusch M., Kunz M., Socher E., Autenrieth SE., Purbojo A., Sirbu H., Hartmann A., Alexiou C., Cesnjevar R., Dudziak D.:
  XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors
  In: Proceedings of the National Academy of Sciences of the United States of America 120 (2023), S. e2300343120
  ISSN: 0027-8424
  DOI: 10.1073/pnas.2300343120
• Tillmanns J., Häge S., Borst EM., Wardin J., Eickhoff J., Klebl B., Wagner S., Wangen C., Hahn F., Socher E., Marschall M.:
  Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target
  In: Cells 12 (2023), Art.Nr.: 1162
  ISSN: 2073-4409
  DOI: 10.3390/cells12081162

2022

• Feldt J., Schicht M., Welss J., Gelse K., Sesselmann S., Tsokos M., Socher E., Garreis F., Mueller T., Paulsen F.:
  Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis
  In: Biomedicines 10 (2022), S. 723
  ISSN: 2227-9059
  DOI: 10.3390/biomedicines10030723
• Peter AS., Grüner E., Socher E., Fraedrich K., Richel E., Müller-Schmucker S., Cordsmeier A., Enßer A., Sticht H., Überla K.:
  Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
  In: International Journal of Molecular Sciences 23 (2022)
  ISSN: 1422-0067
  DOI: 10.3390/ijms23158177
• Schwarz H., Bässler S., Balta D., Socher E., Zunke F., Arnold P.:
  The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders
  In: Behavioural Brain Research 433 (2022), Art.Nr.: 113977
  ISSN: 0166-4328
  DOI: 10.1016/j.bbr.2022.113977
• Schütz M., Müller R., Socher E., Wangen C., Full F., Wyler E., Wong DD., Scherer M., Stamminger T., Chou S., Rawlinson WD., Hamilton ST., Sticht H., Marschall M.:
  Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
  In: International Journal of Molecular Sciences 23 (2022), S. 11814
  ISSN: 1422-0067
  DOI: 10.3390/ijms231911814
• Socher E., Heger L., Paulsen F., Zunke F., Arnold P.:
  Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants
  In: Computational and Structural Biotechnology Journal 20 (2022), S. 1168-1176
  ISSN: 2001-0370
  DOI: 10.1016/j.csbj.2022.02.015

2021

• Li W., Lueckstaedt W., Wöhner B., Bub S., Schulz A., Socher E., Arnold P.:
  Structural and functional properties of meprin β metalloproteinase with regard to cell signaling
  In: Biochimica Et Biophysica Acta-Molecular Cell Research (2021), S. 119136
  ISSN: 0167-4889
  DOI: 10.1016/j.bbamcr.2021.119136
• Peter AS., Roth E., Schulz S., Fraedrich K., Steinmetz T., Damm D., Hauke M., Richel E., Müller-Schmucker S., Habenicht K., Eberlein V., Issmail L., Uhlig N., Dolles S., Grüner E., Peterhoff D., Ciesek S., Hoffmann M., Pöhlmann S., McKay PF., Shattock RJ., Wölfel R., Socher E., Wagner R., Eichler J., Sticht H., Schuh W., Neipel F., Enßer A., Mielenz D., Tenbusch M., Winkler T., Grunwald T., Überla K., Jäck HM.:
  A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model
  In: European Journal of Immunology (2021), Art.Nr.: eji.202149374
  ISSN: 0014-2980
  DOI: 10.1002/eji.202149374
• Schütz M., Steingruber M., Socher E., Müller R., Wagner S., Kögel M., Sticht H., Marschall M.:
  Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
  In: Viruses 13 (2021), S. 1248
  ISSN: 1999-4915
  DOI: 10.3390/v13071248
• Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
  Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation
  In: Journal of Cellular Biochemistry (2021)
  ISSN: 0730-2312
  DOI: 10.1002/jcb.30142
• Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
  Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
  In: Biomedicines 9 (2021)
  ISSN: 2227-9059
  DOI: 10.3390/biomedicines9050525
  URL: https://www.mdpi.com/2227-9059/9/5/525/xml

2020

• Donhauser N., Socher E., Millen S., Heym S., Sticht H., Thoma-Kreß A.:
  Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8
  In: PLoS Pathogens 16 (2020), Art.Nr.: e1008879
  ISSN: 1553-7366
  DOI: 10.1371/journal.ppat.1008879
• Söldner C., Socher E., Jamali V., Wicke W., Ahmadzadeh A., Breitinger HG., Burkovski A., Castiglione K., Schober R., Sticht H.:
  A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems
  In: IEEE Communications Surveys & Tutorials 22 (2020), S. 2765-2800
  ISSN: 1553-877X
  DOI: 10.1109/COMST.2020.3008819

2019

• Papuc S., Abela L., Steindl K., Begemann A., Simmons T., Schmitt B., Zweier M., Oneda B., Socher E., Crowther L., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor M., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
  The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and high-resolution copy number study
  51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
  In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
• Papuc SM., Abela L., Steindl K., Begemann A., Simmons TL., Schmitt B., Zweier M., Oneda B., Socher E., Crowther LM., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor MC., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
  The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study
  In: European journal of human genetics 27 (2019), S. 408-421
  ISSN: 1018-4813
  DOI: 10.1038/s41431-018-0299-8
• Steingruber M., Keller L., Socher E., Ferre S., Hesse AM., Coute Y., Hahn F., Buescher N., Plachter B., Sticht H., Marschall M.:
  Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
  In: Journal of Biological Chemistry 294 (2019), S. 6188-6203
  ISSN: 0021-9258
  DOI: 10.1074/jbc.RA118.007049

2018

• Diewald B., Socher E., Söldner C., Sticht H.:
  Conformational Dynamics of Herpesviral NEC Proteins in Different Oligomerization States
  In: International Journal of Molecular Sciences 19 (2018)
  ISSN: 1422-0067
  DOI: 10.3390/ijms19102908

2017

• König P., Buescher N., Steingruber M., Socher E., Sticht H., Tenzer S., Plachter B., Marschall M.:
  Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions
  In: Journal of General Virology 98 (2017), S. 2850-2863
  ISSN: 0022-1317
  DOI: 10.1099/jgv.0.000939

2016

• Hutterer C., Hamilton S., Steingruber M., Zeitträger I., Bahsi H., Thuma N., Naing Z., Oerfi Z., Oerfi L., Socher E., Sticht H., Rawlinson W., Chou S., Haupt VJ., Marschall M.:
  The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors
  In: Antiviral Research 134 (2016), S. 130-143
  ISSN: 0166-3542
  DOI: 10.1016/j.antiviral.2016.08.005
• Oecal S., Socher E., Uthoff M., Ernst C., Zaucke F., Sticht H., Baumann U., Gebauer JM.:
  The pH-dependent client release from the collagen-specific chaperone HSP47 is triggered by a tandem histidine pair
  In: Journal of Biological Chemistry 291 (2016), S. 12612-12626
  ISSN: 0021-9258
  DOI: 10.1074/jbc.M115.706069
• Socher E., Sticht H.:
  Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
  In: Scientific Reports 6 (2016), Art.Nr.: 22523
  ISSN: 2045-2322
  DOI: 10.1038/srep22523
  URL: http://www.nature.com/articles/srep22523
• Socher E., Sticht H.:
  Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations
  In: Journal of Physical Chemistry B 120 (2016), S. 11845-11855
  ISSN: 1520-6106
  DOI: 10.1021/acs.jpcb.6b06091
• Steingruber M., Kraut A., Socher E., Sticht H., Reichel A., Stamminger T., Amin B., Coute Y., Hutterer C., Marschall M.:
  Proteomic interaction patterns between human cyclins, the cyclin-dependent kinase ortholog pUL97 and additional cytomegalovirus proteins
  In: Viruses 8 (2016), Art.Nr.: 219
  ISSN: 1999-4915
  DOI: 10.3390/v8080219

2015

• Steingruber M., Socher E., Hutterer C., Webel R., Bergbrede T., Lenac T., Sticht H., Marschall M.:
  The interaction between cyclin B1 and cytomegalovirus protein kinase pUL97 is determined by an active kinase domain
  In: Viruses 7 (2015), S. 4582-4601
  ISSN: 1999-4915
  DOI: 10.3390/v7082834

2014

• Socher E., Sticht H., Horn A.:
  The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length
  In: Acs Chemical Neuroscience 5 (2014), S. 161-167
  ISSN: 1948-7193
  DOI: 10.1021/cn400208r

2013

• Rogler A., Hoja S., Socher E., Nolte E., Wach S., Wieland W., Hofstädter F., Goebell P., Wullich B., Hartmann A., Stoehr R.:
  Role of two single nucleotide polymorphisms in secreted frizzled related protein 1 and bladder cancer risk
  In: International Journal of Clinical and Experimental Pathology 6 (2013), S. 1984-1998
  ISSN: 1936-2625
  URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796220/