Eileen Socher

Eileen Socher, Dr. rer. nat.

Habilitandin (wissenschaftliche Mitarbeiterin)

Institut für Funktionelle und Klinische Anatomie

Universitätsstr. 19
91054 Erlangen
Deutschland

IT-Beauftragte

http://orcid.org/0000-0002-6239-3749

Publications

2023

Heger L., Hatscher L., Liang C., Lehmann C., Amon L., Lühr JJ., Kaszubowski T., Nzirorera R., Schaft N., Dörrie J., Irrgang P., Tenbusch M., Kunz M., Socher E., Autenrieth SE., Purbojo A., Sirbu H., Hartmann A., Alexiou C., Cesnjevar R., Dudziak D.:
XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors
In: Proceedings of the National Academy of Sciences of the United States of America 120 (2023), S. e2300343120
ISSN: 0027-8424
DOI: 10.1073/pnas.2300343120
Tillmanns J., Häge S., Borst EM., Wardin J., Eickhoff J., Klebl B., Wagner S., Wangen C., Hahn F., Socher E., Marschall M.:
Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target
In: Cells 12 (2023), Art.Nr.: 1162
ISSN: 2073-4409
DOI: 10.3390/cells12081162

2022

Feldt J., Schicht M., Welss J., Gelse K., Sesselmann S., Tsokos M., Socher E., Garreis F., Mueller T., Paulsen F.:
Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis
In: Biomedicines 10 (2022), S. 723
ISSN: 2227-9059
DOI: 10.3390/biomedicines10030723
Peter AS., Grüner E., Socher E., Fraedrich K., Richel E., Müller-Schmucker S., Cordsmeier A., Enßer A., Sticht H., Überla K.:
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
In: International Journal of Molecular Sciences 23 (2022)
ISSN: 1422-0067
DOI: 10.3390/ijms23158177
Schwarz H., Bässler S., Balta D., Socher E., Zunke F., Arnold P.:
The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders
In: Behavioural Brain Research 433 (2022), Art.Nr.: 113977
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2022.113977
Schütz M., Müller R., Socher E., Wangen C., Full F., Wyler E., Wong DD., Scherer M., Stamminger T., Chou S., Rawlinson WD., Hamilton ST., Sticht H., Marschall M.:
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
In: International Journal of Molecular Sciences 23 (2022), S. 11814
ISSN: 1422-0067
DOI: 10.3390/ijms231911814
Socher E., Heger L., Paulsen F., Zunke F., Arnold P.:
Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants
In: Computational and Structural Biotechnology Journal 20 (2022), S. 1168-1176
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2022.02.015

2021

Li W., Lueckstaedt W., Wöhner B., Bub S., Schulz A., Socher E., Arnold P.:
Structural and functional properties of meprin β metalloproteinase with regard to cell signaling
In: Biochimica Et Biophysica Acta-Molecular Cell Research (2021), S. 119136
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2021.119136
Peter AS., Roth E., Schulz S., Fraedrich K., Steinmetz T., Damm D., Hauke M., Richel E., Müller-Schmucker S., Habenicht KM., Eberlein V., Issmail L., Uhlig N., Dolles S., Grüner E., Peterhoff D., Ciesek S., Hoffmann M., Pöhlmann S., McKay PF., Shattock RJ., Wölfel R., Socher E., Wagner R., Eichler J., Sticht H., Schuh W., Neipel F., Enßer A., Mielenz D., Tenbusch M., Winkler T., Grunwald T., Überla K., Jäck HM.:
A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model
In: European Journal of Immunology (2021), Art.Nr.: eji.202149374
ISSN: 0014-2980
DOI: 10.1002/eji.202149374
Schütz M., Steingruber M., Socher E., Müller R., Wagner S., Kögel M., Sticht H., Marschall M.:
Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
In: Viruses 13 (2021), S. 1248
ISSN: 1999-4915
DOI: 10.3390/v13071248
Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation
In: Journal of Cellular Biochemistry (2021)
ISSN: 0730-2312
DOI: 10.1002/jcb.30142
Socher E., Conrad M., Heger L., Paulsen F., Sticht H., Zunke F., Arnold P.:
Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
In: Biomedicines 9 (2021)
ISSN: 2227-9059
DOI: 10.3390/biomedicines9050525
URL: https://www.mdpi.com/2227-9059/9/5/525/xml

2020

Donhauser N., Socher E., Millen S., Heym S., Sticht H., Thoma-Kreß A.:
Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8
In: PLoS Pathogens 16 (2020), Art.Nr.: e1008879
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1008879
Söldner C., Socher E., Jamali V., Wicke W., Ahmadzadeh A., Breitinger HG., Burkovski A., Castiglione K., Schober R., Sticht H.:
A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems
In: IEEE Communications Surveys & Tutorials 22 (2020), S. 2765-2800
ISSN: 1553-877X
DOI: 10.1109/COMST.2020.3008819

2019

Papuc S., Abela L., Steindl K., Begemann A., Simmons T., Schmitt B., Zweier M., Oneda B., Socher E., Crowther L., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor M., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and high-resolution copy number study
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) (Milan, ITALY, 16. Juni 2018 - 19. Juni 2018)
In: EUROPEAN JOURNAL OF HUMAN GENETICS, LONDON: 2019
Papuc SM., Abela L., Steindl K., Begemann A., Simmons TL., Schmitt B., Zweier M., Oneda B., Socher E., Crowther LM., Wohlrab G., Gogoll L., Poms M., Seiler M., Papik M., Baldinger R., Baumer A., Asadollahi R., Kroell-Seger J., Schmid R., Iff T., Schmitt-Mechelke T., Otten K., Hackenberg A., Addor MC., Klein A., Azzarello-Burri S., Sticht H., Joset P., Plecko B., Rauch A.:
The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study
In: European journal of human genetics 27 (2019), S. 408-421
ISSN: 1018-4813
DOI: 10.1038/s41431-018-0299-8
Steingruber M., Keller L., Socher E., Ferre S., Hesse AM., Coute Y., Hahn F., Buescher N., Plachter B., Sticht H., Marschall M.:
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
In: Journal of Biological Chemistry 294 (2019), S. 6188-6203
ISSN: 0021-9258
DOI: 10.1074/jbc.RA118.007049

2018

Diewald B., Socher E., Söldner C., Sticht H.:
Conformational Dynamics of Herpesviral NEC Proteins in Different Oligomerization States
In: International Journal of Molecular Sciences 19 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19102908

2017

König P., Buescher N., Steingruber M., Socher E., Sticht H., Tenzer S., Plachter B., Marschall M.:
Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions
In: Journal of General Virology 98 (2017), S. 2850-2863
ISSN: 0022-1317
DOI: 10.1099/jgv.0.000939

2016

Hutterer C., Hamilton S., Steingruber M., Zeitträger I., Bahsi H., Thuma N., Naing Z., Oerfi Z., Oerfi L., Socher E., Sticht H., Rawlinson W., Chou S., Haupt VJ., Marschall M.:
The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors
In: Antiviral Research 134 (2016), S. 130-143
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2016.08.005
Oecal S., Socher E., Uthoff M., Ernst C., Zaucke F., Sticht H., Baumann U., Gebauer JM.:
The pH-dependent client release from the collagen-specific chaperone HSP47 is triggered by a tandem histidine pair
In: Journal of Biological Chemistry 291 (2016), S. 12612-12626
ISSN: 0021-9258
DOI: 10.1074/jbc.M115.706069
Socher E., Sticht H.:
Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins
In: Scientific Reports 6 (2016), Art.Nr.: 22523
ISSN: 2045-2322
DOI: 10.1038/srep22523
URL: http://www.nature.com/articles/srep22523
Socher E., Sticht H.:
Probing the Structure of the Escherichia coli Periplasmic Proteins HdeA and YmgD by Molecular Dynamics Simulations
In: Journal of Physical Chemistry B 120 (2016), S. 11845-11855
ISSN: 1520-6106
DOI: 10.1021/acs.jpcb.6b06091
Steingruber M., Kraut A., Socher E., Sticht H., Reichel A., Stamminger T., Amin B., Coute Y., Hutterer C., Marschall M.:
Proteomic interaction patterns between human cyclins, the cyclin-dependent kinase ortholog pUL97 and additional cytomegalovirus proteins
In: Viruses 8 (2016), Art.Nr.: 219
ISSN: 1999-4915
DOI: 10.3390/v8080219

2015

Steingruber M., Socher E., Hutterer C., Webel R., Bergbrede T., Lenac T., Sticht H., Marschall M.:
The interaction between cyclin B1 and cytomegalovirus protein kinase pUL97 is determined by an active kinase domain
In: Viruses 7 (2015), S. 4582-4601
ISSN: 1999-4915
DOI: 10.3390/v7082834

2014

Socher E., Sticht H., Horn A.:
The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length
In: Acs Chemical Neuroscience 5 (2014), S. 161-167
ISSN: 1948-7193
DOI: 10.1021/cn400208r

2013

Rogler A., Hoja S., Socher E., Nolte E., Wach S., Wieland W., Hofstädter F., Goebell P., Wullich B., Hartmann A., Stoehr R.:
Role of two single nucleotide polymorphisms in secreted frizzled related protein 1 and bladder cancer risk
In: International Journal of Clinical and Experimental Pathology 6 (2013), S. 1984-1998
ISSN: 1936-2625
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796220/

Awards

Poster Award

31st Molecular Modelling Workshop
Erlangen, Germany, March 2017
“Structural investigation of the E. coli proteins HdeA and YmgD by MD simulations”

Best Poster Award

Biophysics 2016
Erlangen, Germany, September 2016
“Probing the structure of the Escherichia coli proteins HdeA and YmgD by pH-titrating MD simulations”

Best Poster Award, first place

7th Annual Retreat, Erlangen School of Molecular Communication
Schloss Hirschberg, Beilngries, Germany, July 2015
“pH-Dependent Regulation of Proteins: From Viruses to Plants”

Poster Presentation Award, third place

Research Day, Emil Fischer Graduate Programme
Erlangen, Germany, July 2015
“pH-Dependent Regulation of Proteins: From Viruses to Plants”

Best Talk Award, first place

6th Annual Retreat, Erlangen School of Molecular Communication
Kloster Banz, Bad Staffelstein, Germany, July 2014
“pH-Dependent Dissociation of HdeA Dimers – How Bacteria Survive an Acid Trip”

Poster Prize of the IZKF Erlangen

5th International IZKF-Symposium “Translational Medicine”
Kloster Banz, Bad Staffelstein, Germany, May 2014
“The Stability of a Nonfibrillar Amyloid-β Tetramer Structure Depends Critically on C-terminal Peptide Length”

Talks and Posters

Talks

February 2022	Guest lecture in the Institute for Clinical and Molecular Virology, Erlangen, Germany “SARS-CoV-2 Spike Protein: Molecular Dynamics Simulations of Sequence Variants Compared to the Wild Type Protein”
September 2021	115th Anatomische Gesellschaft Annual Meeting (online), Innsbruck, Austria “SARS-CoV-2 Spike Protein: Molecular Dynamics Simulations of Sequence Variants Compared to the Wild Type Protein”
July 2020	65. Anatomisches Kolloquium, Erlangen, Germany “Computerbasierte Analyse von pH-induzierten Effekten auf die Proteinstruktur”
April 2016	30th Molecular Modelling Workshop, Erlangen, Germany “Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins”
July 2014	6th Annual Retreat, Erlangen School of Molecular Communication, Kloster Banz, Bad Staffelstein, Germany “pH-Dependent Dissociation of HdeA Dimers – How bacteria survive an acid trip”
July 2013	5th Annual Retreat, Erlangen School of Molecular Communication, Kloster Banz, Bad Staffelstein, Germany “Computational investigation of pH-dependent effects on protein structure and interaction”

Posters

March 2023	35th Molecular Modelling Workshop, Erlangen, Germany “Molecular Case Study of a GALC Mutation Causing Infantile Krabbe Disease”
September 2022	116th Annual Meeting of the Anatomische Gesellschaft, Berlin, Germany “SARS-CoV-2 spike protein variants interact differently with human receptor ACE2”
June 2022	8th International IZKF-Symposium, Kloster Banz, Bad Staffelstein, Germany “SARS-CoV-2 spike protein variants interact differently with human receptor ACE2”
March 2017	31st Molecular Modelling Workshop, Erlangen, Germany “Structural investigation of the E. coli proteins HdeA and YmgD by MD simulations”
March 2017	Workshop on Computer Simulation and Theory of Macromolecules 2017, Hünfeld, Germany “Structural Investigation of the E. coli Proteins HdeA and YmgD by MD Simulations”
October 2016	8th Annual Retreat, Erlangen School of Molecular Communication, Schloss Schney, Lichtenfels, Germany “Probing the structure of the Escherichia coli proteins HdeA and YmgD by pH-titrating MD simulations”
October 2016	Biophysics 2016, Erlangen, Germany “Probing the structure of the Escherichia coli proteins HdeA and YmgD by pH-titrating MD simulations”
September 2016	German Conference on Bioinformatics 2016, Berlin, Germany “Molecular Dynamics Studies on the pH-Dependent Regulation of Proteins: From Viruses to Plants”
May 2016	Workshop on Computer Simulation and Theory of Macromolecules 2016, Hünfeld, Germany “Investigation of pH-dependent effects on proteins by mimicking pH titration experiments with MD simulations”
April 2016	30th Molecular Modelling Workshop, Erlangen, Germany “Investigation of pH-dependent effects on proteins by mimicking pH titration experiments with MD simulations”
October 2015	2nd International SFB 796 Conference: Mechanisms of microbial host cell manipulation: From plants to humans, Erlangen, Germany “Acid Stress Chaperones of E. coli During the Passage through the Host’s Stomach – Observation of a pH-Dependent Dissociation in Molecular Dynamics Simulations”
July 2015	7th Annual Retreat, Erlangen School of Molecular Communication, Schloss Hirschberg, Beilngries, Germany “pH-Dependent Regulation of Proteins: From Viruses to Plants”
July 2015	Research Day, Emil Fischer Graduate Programme, Erlangen, Germany “pH-Dependent Regulation of Proteins: From Viruses to Plants”
April 2015	Workshop on Computer Simulation and Theory of Macromolecules 2015, Hünfeld, Germany “pH-Dependent Dissociation of HdeA and HdeB Dimers – How E. coli Survives an Acid Trip”
March 2015	29th Molecular Modelling Workshop, Erlangen, Germany “pH-Dependent Dissociation of HdeA and HdeB Dimers”
May 2014	5th International IZKF-Symposium “Translational Medicine”, Kloster Banz, Bad Staffelstein, Germany “The Stability of a Nonfibrillar Amyloid-β Tetramer Structure Depends Critically on C-terminal Peptide Length”
April 2014	Workshop on Computer Simulation and Theory of Macromolecules 2014, Hünfeld, Germany “Computational Investigation of the Hsp47-Collagen Interaction”
March 2014	28th Molecular Modelling Workshop, Erlangen, Germany “H238N Mutant of Hsp47: Molecular Mechanism of Disrupted Collagen Binding”
July 2013	Research Day, Emil Fischer Graduate Programme, Erlangen, Germany “New Amyloid-β Tetramer Structure: Evidence of Conformational Stability”
April 2013	Workshop on Computer Simulation and Theory of Macromolecules 2013, Hünfeld, Germany “New Amyloid-β Tetramer Structure: Evidence of Conformational Stability”
February 2013	27th Molecular Modelling Workshop, Erlangen, Germany “Amyloid-β Tetramer: Structural Stability of a New Fold”
March 2012	26th Molecular Modelling Workshop, Erlangen, Germany “Tetramer of Chimeric Aβ-IgNARs as a Model for Amyloid-β Oligomer Formation in Alzheimer’s Disease”